Seroquel Indications and Usage (Schizophrenia)
The drug should be taken exactly as prescribed by your doctor, do not take it longer than recommended or in larger doses. Seroquel can be taken with or without food.
When Seroquel is used to treat schizophrenia in adults, an initial dose of 25mg is administered daily. The dose may be increased to 50mg divided in 2 or 3 doses on the second and third day, if well tolerated; the daily dose on the fourth day may be 300mg up to 400mg.
Further dosage adjustments are indicated at intervals of 2 or more days as steady state for the drug would not be succeeded for approximately 1-2 days in the typical patient.
It is noted that most efficacy data with this drug were got using it 3 times daily in dosing regiments. The results of trial 225mg given twice a day under control were also positive.
The efficacy of the drug was demonstrated in clinical trial when 150mg per day to 750 mg per day were administered to adult patients.
In some cases doses above 300 mg per day were not more effective than 300 mg per day. In other cases larger doses were required, doses in the range of 400mg -500 mg per day. It is not recommended to use the doses above 800 mg per day, because their efficacy and safety were not clinically tested and evaluated.
Young people (13-17 years) are usually administered the drug to take 2 times a day. Still the drug may be given three times a day if needed.
The therapy consists of 5 days; the first day dose is usually 50mg, the second day 100mg, the 3rd day 200mg, the 4th day 300mg and the 5th day 400mg. After the 5th day the dose is adjusted within the recommended range of 400 to 800mg per day it depends on the response to the therapy and tolerance of the patient.
Young patients should be controlled regularly and if necessary the dose adjustments should be altered.
Свежие комментарии