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Seroquel is to be administered with much caution to older patients and patients with serious diseases of kidneys and liver.

Geriatrics may be more sensitive to the effects of Seroquel so they should start with a lower dose. The same dosing recommendation is for those patients who feel weakness or are predisposed to hypotensive reactions. These patients should be monitored regularly by their doctors.

Patients with liver dysfunction should be initiated with 25 mg per day. The dose may be increased daily in increments of 25mg per day – 50 mg per day to an effective dose. The treatment in such patients strongly depends on their clinical response and tolerability.

For patients who have previously stopped or discontinued the treatment with Seroquel and had an interval of less than a week off this medication, the dose of Seroquel may be reinitiated. For those patients who have had a period without Seroquel for more than a week, the initial titration schedule should be taken.